Abstract
BACKGROUND: Gastritis cystica profunda (GCP) is a rare gastric disorder. It is characterized by non-specific symptoms and diagnostic complexity. This case report enriches the medical literature by highlighting challenges in diagnosing and treating GCP. CASE SUMMARY: Two patients presented with non-specific abdominal symptoms, such as abdominal distension and epigastric discomfort. Initial misdiagnosis occurred due to GCP's non-typical manifestations. After thorough investigations, GCP was diagnosed. Endoscopic mucosal resection and endoscopic submucosal dissection were carried out. Both patients recovered uneventfully. CONCLUSION: GCP diagnosis demands caution, and endoscopic treatment is effective.