Abstract
Burnout is a critical problem among healthcare professionals worldwide, but nationally representative data on psychosocial factors associated with burnout are lacking for Latvia's hospital system. This study investigated twofold aims: first, it examined the association between job-related demands, psychosocial resources, and burnout in a representative sample of Latvian hospital staff; and second, it tested whether specific resources buffer or amplify the impact of excessive workload. A cross-sectional survey was conducted among 4756 healthcare workers across 30 inpatient institutions in Latvia. Participants completed the Copenhagen Psychosocial Questionnaire III and the Burnout Assessment Tool; regression and moderation analyses were used. Burnout was positively associated with longer working hours, multiple job-holding, and psychosocial demands such as emotional strain, time pressure, and work-life conflict. Several resources, including support from colleagues, supervisor support, recognition, sense of belonging, supervisor evaluation, and especially resources for quality work, were associated with lower burnout and weakened the relationship between workload and burnout. In contrast, high autonomy, meaning at work, organizational justice, and role conflict amplified this association. These findings suggest that in resource-constrained healthcare systems, some job resources may be associated with increased risk of burnout. Effective interventions should address both structural and relational factors to mitigate burnout among healthcare workers.