Abstract
This study investigated the pharmaceutical potential of extracts from Ammi visnaga (Ammi) and Petroselinum crispum (Parsley), specifically focusing on their antioxidant activity, total phenolic content, and efficacy in disintegrating calcium oxalate kidney stones. Ammi and Parsley extracts, known for their traditional medicinal uses, contain bioactive compounds with significant antioxidant properties that have attracted attention in pharmaceutical research. Oxidative stress, a key factor in various physiological disorders, underscores the importance of antioxidants in the mitigation of cellular damage. Our investigation revealed concentration-dependent enhancements in antioxidant activity and total phenolic content in both Ammi and Parsley extracts, indicating their potential as natural antioxidant agents. Furthermore, both extracts were effective in reducing the size of calcium oxalate stones, with the Ammi extract demonstrating superior stone-disintegration properties. Dissolution studies have provided valuable insights into the release kinetics of phenolic compounds and antioxidant activity, suggesting sustained therapeutic potential. Overall, Ammi and Parsley extracts show promise in pharmaceutical development, offering alternative therapeutic avenues for managing oxidative stress-related conditions and kidney stone formation.