Abstract
Introduction Cardiovascular diseases (CVDs) remain the leading cause of mortality globally. The role of micronutrients in maintaining cardiovascular health has gained increasing attention, as deficiencies or imbalances in vitamins, minerals, and amino acids may influence the risk and progression of CVDs. This study aimed to evaluate the relationship between serum micronutrient levels and critical lipid and lipoprotein markers indicative of cardiovascular health. Materials and methods A retrospective analysis was conducted on 358 individuals who underwent testing for the Cardio Health and Micronutrients Panel at Vibrant America Clinical Laboratory. The participants were divided into three groups based on their serum lipid and lipoprotein concentrations: 'Low', 'Normal', and 'High'. The levels of vitamins (A, D, E, and K), minerals (zinc, iron, calcium, and magnesium), and amino acids (leucine, isoleucine, and valine) were measured, and their correlation with cardiovascular markers such as cholesterol, LDL, HDL, and Apo B was analyzed using Pearson's correlation. Results The study found significant associations between micronutrient levels and cardiovascular markers. Vitamins D, E, and K and minerals like zinc, calcium, and magnesium showed positive correlations with lipid markers. Asparagine was negatively correlated with cholesterol and LDL, while amino acids such as isoleucine and valine negatively correlated with HDL but showed a positive association with LDL and Apo B. Fat-soluble vitamins demonstrated strong positive associations with total cholesterol and triglycerides. Conclusion These findings suggest that certain micronutrients play a critical role in regulating lipid profiles and overall cardiovascular health. Further studies are necessary to explore the therapeutic potential of micronutrient supplementation in preventing or managing CVDs.