Abstract
To assess macular and optic disc choriocapillary flow deficit (CCFD) and vessel density (VD) in myopic children by OCT-angiography. 280 eyes of 280 subjects were included and divided into the non-myopia (n = 96), low myopia (n = 95), and moderate myopia (n = 89) groups. We analyzed the following factors: CCFD density and size, choroidal vascularity index, choriocapillary VD, retinal VD. The moderate myopia group showed significantly higher CCFD density and size (p < 0.05). There were significant linear correlations between CCFD density and axial length (AL), spherical equivalent (SE), average corneal curvature (AVK), and CCFD size and SE (all p < 0.05). Breakpoints were identified at SE values of -1.25 and -1.14D in relation to CCFD density and CCFD size (all p < 0.05). The moderate myopia group exhibited significantly increased and decreased radial peripapillary capillaries VD and retinal nerve fiber layer thickness in the temporal and nasal optic disc regions respectively (all p < 0.05). CCFD demonstrated a significant increase and correlation with AL and SE, suggesting that CCFD may serve as a more sensitive indicator of alternations in choroidal blood flow. It offers a novel perspective for investigating myopia progression associated with alterations in choroidal blood flow.Trial registration number ChiCTR2400087513.