Abstract
PURPOSE: The objective was to evaluate the immediate impact of Goldmann Applanation Tonometry (GAT), a gold-standard intraocular pressure measurement technique, on the reliability of central corneal thickness (CCT) measurements and to compare the outcomes between contact and non-contact pachymetry methods. METHODS: Fifty-one adult participants without ocular pathology were enrolled. Serial CCT measurements were conducted using three different pachymetry modalities across three days, both at baseline and post-GAT: Day 1 with an ultrasound pachymeter (USP), Day 2 using optical low-coherence reflectometry (OLCR), and Day 3 via anterior segment optical coherence tomography (AS-OCT). The study involved comparing mean CCT and CCT standard deviation at baseline and post-GAT using one-way analysis of variance (ANOVA) and paired t-tests. RESULTS: In the 610 CCT measurements performed, mean CCT did not show significant changes post-GAT overall or by modality (USP: +2.20 microns, p=0.63; OLCR: +1.0 microns, p=0.93; AS-OCT: +0.40 microns, p=0.95). However, contact USP consistently produced thicker corneal readings than non-contact OLCR and AS-OCT both at baseline and post-GAT (p < 0.0001). Notably, there was a significant increase in CCT standard deviation (+51.1%) and a decrease in adherence to technical repeatability specifications with contact USP following GAT (from 55% to 33%, p < 0.05). CONCLUSIONS: The study suggests that contact intraocular pressure measurement methods like GAT may influence the reliability and repeatability of CCT measurements, as observed in our increased CCT measurement standard deviations. This could have important implications for accurate diagnosis and treatment planning for various ocular conditions. Given the study's limited sample size, further research may be warranted.