Abstract
Osteoporosis, a skeletal disorder that reduces bone density, is a significant health concern. Alcohol dependence, a chronic condition, exacerbates public health problems due to its widespread occurrence and association with various comorbidities, including depression. This study aims to explore the relationship between monocyte to high-density lipoprotein cholesterol ratio (MHR) and lumbar bone mineral density (BMD)in individuals with alcohol dependence and depression. From 2009 to 2018, 49,693 participants were enrolled, and after screening, the study included 2,055 individuals with alcohol-dependency and depression. In this study, multivariate regression analysis was employed to assess the association between monocyte to HDL-C ratio and lumbar bone mineral density. Additionally, we conducted interaction tests and subgroup analysis. The result showed a negative correlation between MHR and lumbar BMD, which remained significant even after adjusting for covariates. Individuals with less than a 9th-grade education showed a positive link with MHR, while those with a college degree or higher had a negative link. This relationship remained significant in the fully adjusted model. A U-shaped relationship between MHR and lumbar BMD was observed in individuals with a high school diploma/GED, after adjusting for various factors. The intricate correlation between MHR and lumbar BMD may suggest the presence of biological interplays and disparities in socioeconomic or behavioral aspects. This underscores the necessity for tailored public health strategies that cater to various educational demographics.