An insight into real-world practice: What information sources inform the prescribing for children with cancer in Scotland? A focus on emesis, tumour lysis syndrome (TLS), and Pneumocystis Pneumonia (PCP) prophylaxis

深入了解真实世界实践:苏格兰儿童癌症患者的处方用药依据哪些信息来源?重点关注呕吐、肿瘤溶解综合征 (TLS) 和卡氏肺囊虫肺炎 (PCP) 的预防。

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Abstract

Within clinical practice, information sources such as clinical guidelines ensure practitioners apply evidence-based information, supporting both effectiveness and safety of the prescribed medicines. Paediatric cancer - a leading cause of death in children - is a complex condition, thus is an area where clinical guidelines are important to give guidance on, e.g., recommended doses, drug dispensing, and toxicity monitoring measures. However, exploring clinical guidelines/information sources and their content regarding medicine-pertaining aspects is rarely done despite the fact they directly inform patient care. This comment summarises the main findings of a document analysis study aimed to describe available documents and their content for Scotland-based paediatric prescribers in oncology wards and provides insights into the documents' comprehensiveness and consistency. The analysis covered three clinical indications which are either highly prevalent or troublesome in practice: emesis, tumour lysis syndrome (TLS), and Pneumocystis Pneumonia (PCP) prophylaxis.

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