Abstract
Although the rate of total hip arthroplasty (THA) is declining among rheumatoid arthritis (RA) patients, the complex etiology of RA and associated immunomodulatory therapies may contribute to elevated risks of postoperative complications. This study aimed to evaluate in-hospital complications following THA in RA patients compared to osteoarthritis (OA) patients using a Japanese nationwide database. This retrospective study analyzed data from the Diagnosis Procedure Combination database, including THA patients between December 2011 and March 2023. The RA and OA groups were matched in a one-to-three ratio using propensity scores, considering factors such as age, sex, and comorbidities. Multivariate logistic regression was conducted to assess independent risk factors for complications. Among 353,465 patients, 3,977 underwent THA for RA and 298,326 for OA. After matching, 3,951 RA and 11,853 OA patients were included. RA was an independent risk factor for dislocation (OR: 2.783, 95% CI 1.641-4.720) and reoperation (OR: 2.254, 95% CI 1.687-3.013). No significant differences were observed in infection, periprosthetic fracture, venous thromboembolism, or mortality. RA patients undergoing THA are at higher risk for dislocation and reoperation. These findings emphasize the need for careful surgical planning and implementation to improve outcomes in RA patients.