"Marriage" of Inorganic to Organic Chemistry as Motivation for a Theoretical Study of Chloroform Hydrolysis Mechanisms

无机化学与有机化学的“结合”:氯仿水解机理理论研究的动机

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Abstract

Incorporation of chlorides in coordination complexes, prepared by reactions in CHCl(3), stimulated MP2 and DFT studies of its complete hydrolysis mechanisms. In excellent agreement with previous experimental results, the most important mechanism for CHCl(3) basic hydrolysis at room temperature is the radical one producing :CCl(2). The latter inserts into the H-O bond of H(2)O yielding dichloromethanol (1). The hydrolysis mechanism of α-H-lacking PhCCl(3) to the corresponding dichloro(phenyl)methanol (3) was also studied. 1 decomposes by H(2)O to formyl chloride (2) and HCl. 2, following a variety of pathways, leads to known CHCl(3) hydrolysis products, such as CO (4) and formic acid (6), via the intermediates chloromethanediol (5), s-cis, s-trans-dihydroxycarbene (ct-7), and s-trans, s-trans-dihydroxycarbene (tt-7). Interestingly, both ct-7 and tt-7 intermediates have recently been implicated in the reduction of CO(2) with H(2) to 6. The conversion of CO to HCOOH was studied. Most of the reactions studied are asynchronous concerted processes, the radical mechanism being a multistep one. The synthetic utility of this mechanism is briefly mentioned. To avoid chloride ions when performing reactions in CHCl(3), we should use the solvent at room temperature even in the presence of water. This has been verified further by coordination chemistry reactions in progress.

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