Abstract
OBJECTIVES: The challenges in diagnosing keratoconus (KC) have led researchers to explore the use of artificial intelligence (AI) as a diagnostic tool. AI has emerged as a new way to improve the efficiency of KC diagnosis. This study analyzed the use of AI as a diagnostic modality for KC. METHODS: This study used a systematic review and meta-analysis following the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We searched selected databases using a combination of search terms: "((Artificial Intelligence) OR (Diagnostic Modality)) AND (Keratoconus)" from PubMed, Medline, and ScienceDirect within the last 5 years (2018-2023). Following a systematic review protocol, we selected 11 articles and 6 articles were eligible for final analysis. The relevant data were analyzed with Review Manager 5.4 software and the final output was presented in a forest plot. RESULTS: This research found neural networks as the most used AI model in diagnosing KC. Neural networks and naïve bayes showed the highest accuracy of AI in diagnosing KC with a sensitivity of 1.00, while random forests were >0.90. All studies in each group have proven high sensitivity and specificity over 0.90. CONCLUSIONS: AI potentially makes a better diagnosis of the KC with its high performance, particularly on sensitivity and specificity, which can help clinicians make medical decisions about an individual patient.