Abstract
Periorbital cellulitis and angioedema can present with similar clinical features, posing a diagnostic challenge. We describe a case of a 71-year-old female patient with a past history of hypertension and diabetes who developed facial swelling and erythema following trauma. She was initially treated for periorbital cellulitis but was later found to have concurrent angioedema, likely triggered by antibiotics and herbal supplements. This report emphasizes the importance of thorough clinical evaluation, timely imaging, and consideration of alternative diagnoses to guide appropriate management.