Abstract
Endodontic success depends on accurate diagnosis, complete debridement of diseased pulp tissue, and adequate disinfection of the root canal system. It is essential to have a solid grasp of root canal variations. Inadequate knowledge of complex root canal configurations can lead to missed canals, failure to negotiate canal deviations, bifurcations, trifurcations, anastomoses, fins, and isthmuses, thereby complicating treatment. This case series focuses on the importance of diagnosis, radiographic interpretation, and treatment planning in managing maxillary first premolars and mandibular second premolars with aberrant canal anatomy.