Conclusion
The incorporation of essential oils in Orabase could help in future drug delivery design, with promising outcomes on patients' well-being.
Methods
Orabase loaded with clove oil, thyme oil, eugenol, and thymol were prepared and evaluated for their antifungal activities, pH, viscosity, erosion and water uptake characteristics, mechanical properties, in vitro release behavior, and ex vivo mucoadhesion properties.
Purpose
Oral candidiasis may be manifested in the oral cavity as either mild or severe oral fungal infection. This infection
Results
All prepared bases showed considerable antifungal activity and acceptable physical characteristics. The release pattern from loaded bases was considerably slow for all oils and active ingredients. All bases showed appreciable adhesion in the in vitro and ex vivo studies.