Abstract
Ca(2+) is pivotal intracellular messenger that coordinates multiple cell functions such as fertilization, growth, differentiation, and viability. Intracellular Ca(2+) signaling is regulated by both extracellular Ca(2+) entry and Ca(2+) release from intracellular stores. Apart from working as the cellular recycling center, the lysosome has been increasingly recognized as a significant intracellular Ca(2+) store that provides Ca(2+) to regulate many cellular processes. The lysosome also talks to other organelles by releasing and taking up Ca(2+). In lysosomal Ca(2+)-dependent processes, autophagy is particularly important, because it has been implicated in many human diseases including cancer. This review will discuss the major components of lysosomal Ca(2+) stores and their roles in autophagy and human cancer progression.