Induction of mouse melioidosis with meningitis by CD11b+ phagocytic cells harboring intracellular B. pseudomallei as a Trojan horse
CD11b+ 吞噬细胞携带胞内类鼻疽杆菌作为特洛伊木马，从而诱发小鼠类鼻疽脑膜炎
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作者：Pei-Ju Liu, Yao-Shen Chen, Hsi-Hsu Lin, Wei-Feng Ni, Tsung-Han Hsieh, Hsu-Tzu Chen, Ya-Lei Chen
Background
Approximately 3-5% of patients with melioidosis manifest CNS symptoms; however, the clinical data regarding neurological melioidosis are limited.
Significance
We suggest that B. pseudomallei-infected CD11b(+) selectin-expressing cells act as a Trojan horse and are able to transmigrate across endothelial cells, resulting in melioidosis with meningitis.
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