Synthesis of bioactive polyaniline- b-polyacrylic acid copolymer nanofibrils as an effective antibacterial and anticancer agent in cancer therapy, especially for HT29 treatment

生物活性聚苯胺-b-聚丙烯酸共聚物纳米纤维的合成,作为癌症治疗中的有效抗菌和抗癌剂,特别是用于 HT29 治疗

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作者:Nazanin Bagheri, Moslem Mansour Lakouraj, Seyed Reza Nabavi, Hamed Tashakkorian, Mojtaba Mohseni

Abstract

In this work, a new highly water-soluble copolymer of polyacrylic acid with polyaniline is introduced. Acrylic acid was polymerized via the Reversible Addition Fragmentation Chain Transfer method (RAFT) in the presence of an initiator and the obtained polyacrylic acid was copolymerized with aniline at room temperature. As the main achievements of this work, the resulting block copolymer with nanosized structure revealed favorable solubility in polar solvents, as well as excellent antibacterial and anticancer activities. Therefore, it is an appropriate candidate for medical applications such as wound healing and cancer therapy, especially in HT29 treatment.

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