The mannose receptor mediates the cellular immune response in human coccidioidomycosis

甘露糖受体介导人类球孢子菌病的细胞免疫反应

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作者:Neil M Ampel, Daniel K Nelson, Lijin Li, Sara O Dionne, Douglas F Lake, Keira A Simmons, Demosthenes Pappagianis

Abstract

Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K. These data suggest that MR mediates IL-2 release by T27K.

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