Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone

柴油机尾气颗粒对肺和心血管系统的对比作用以及百里香醌的影响

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作者：Abderrahim Nemmar, Suhail Al-Salam, Shaheen Zia, Fatima Marzouqi, Amna Al-Dhaheri, Deepa Subramaniyan, Subramanian Dhanasekaran, Javed Yasin, Badreldin H Ali, Elsadig E Kazzam
期刊：British Journal of Pharmacology影响因子：6.800
时间：2011起止号：2011 Dec;164(7):1871-82.
doi：10.1111/j.1476-5381.2011.01442.x研究方向： 心血管

Background and purpose

Acute exposure to particulate air pollution has been linked to acute cardiopulmonary events, but the underlying mechanisms are uncertain. EXPERIMENTAL APPROACH We investigated the acute (at 4 and 18 h) effects of diesel exhaust particles (DEP) on cardiopulmonary parameters in mice and the protective effect of thymoquinone, a constituent of Nigella sativa. Mice were given, intratracheally, either saline (control) or DEP (30 µg·per mouse). KEY

Purpose

Acute exposure to particulate air pollution has been linked to acute cardiopulmonary events, but the underlying mechanisms are uncertain. EXPERIMENTAL APPROACH We investigated the acute (at 4 and 18 h) effects of diesel exhaust particles (DEP) on cardiopulmonary parameters in mice and the protective effect of thymoquinone, a constituent of Nigella sativa. Mice were given, intratracheally, either saline (control) or DEP (30 µg·per mouse). KEY

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