Serum Free Fatty Acid Changes Caused by High Expression of Stearoyl-CoA Desaturase 1 in Tumor Tissues Are Early Diagnostic Markers for Ovarian Cancer

肿瘤组织中硬脂酰辅酶A去饱和酶1高表达引起的血清游离脂肪酸变化是卵巢癌的早期诊断标志物

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作者:Kanoko Katoh #, Yuki Katoh #, Akiko Kubo #, Miho Iida, Yuji Ikeda, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Makoto Suematsu, Shuichi Hirai, Kei Kawana

Significance

Measurement of serum FFA levels by changes in the expression of fatty acid metabolizing enzymes in tumor tissue would allow early detection of ovarian cancer. In particular, the SCD1-associated FFAs, oleic and arachidic acid, would be powerful new screening tools for early-stage ovarian cancer.

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