Maturation of gastric electrical activity, gastric emptying and intestinal permeability in preterm newborns during the first month of life

早产儿出生后第一个月内胃电活动、胃排空和肠道通透性的成熟

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作者:Giuseppe Riezzo, Flavia Indrio, Francesco Raimondi, Osvaldo Montagna, Gennaro Salvia, Bisceglia Massimo, Lorenzo Polimeno, Luciano Cavallo, Ruggiero Francavilla

Conclusion

In preterm healthy newborns of 34 weeks gestational age, electrical and motor activity are completely developed at birth whilst the intestinal epithelial barrier clearly improves during the first week of life.

Methods

Eighteen preterm newborns (median 34 wks, range 2 wks) completed the study. They underwent the recording of gastric electrical activity by means of cutaneous electrogastrography, the ultrasound examination of gastric emptying, and the lactulose-to-mannitol ratio from permeability-absorption test on days 3, 7, 15, and 30 after birth.

Results

Gastric electrical activity and emptying showed only slight changes between day 3 and day 7. On the contrary, an evident maturation in permeability, expressed as L/Mratio, was evident over time (Friedman Repeated Measures Analysis, p = 0.004).

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