Mesenchymal Stromal Cell-Derived Factors Promote Tissue Repair in a Small-for-Size Ischemic Liver Model but Do Not Protect against Early Effects of Ischemia and Reperfusion Injury
间充质基质细胞衍生因子促进小型缺血性肝脏模型中的组织修复,但不能防止缺血和再灌注损伤的早期影响
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作者:Suomi M G Fouraschen, Joshua H Wolf, Luc J W van der Laan, Petra E de Ruiter, Wayne W Hancock, Job P van Kooten, Monique M A Verstegen, Kim M Olthoff, Jeroen de Jonge
Conclusion
Mesenchymal stromal cell-derived factors promote tissue regeneration of small-for-size livers exposed to ischemic conditions but do not protect against early ischemia and reperfusion injury itself. MSC-derived factors therefore represent a promising treatment strategy for small-for-size syndrome and postresectional liver failure.
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