Isolation of a human monoclonal antibody with strong neutralizing activity against diphtheria toxin
具有强中和活性的抗白喉毒素人单克隆抗体的分离
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作者：Mai Kakita, Tsuyoshi Takahashi, Takako Komiya, Yoshitaka Iba, Takao Tsuji, Yoshikazu Kurosawa, Motohide Takahashi
Abstract
We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (Kd) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the traditional equine sera.
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