Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2
泛素连接酶活性测定：HDM2 抑制剂的高通量筛选
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作者：I V Davydov, D Woods, Y J Safiran, P Oberoi, H O Fearnhead, S Fang, J P Jensen, A M Weissman, J H Kenten, K H Vousden
Abstract
An assay for the autoubiquitination activity of the E3 ligase HDM2 (Mdm2) was developed and adapted to a high-throughput format to identify inhibitors of this activity. The assay can also be used to measure the activity of other E3s and may be useful in finding both inhibitors and activators of a wide range of different ubiquitin ligases.
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