Milk lymphocyte profile and macrophage functions: new insights into the immunity of the mammary gland in quarters infected with Corynebacterium bovis

乳淋巴细胞谱和巨噬细胞功能:对感染牛棒状杆菌的场所乳腺免疫的新见解

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作者:Vitória M Silva, Marina T Souza, Maiara G Blagitz, Fernando N Souza, Camila F Batista, Alexandre J Alves, Artur C C Fernandes, Eduardo M R Sanchez, Carla M Ordinola-Ramirez, Luciana da Costa, Alice M M P Della Libera

Conclusions

Thus, our results corroborate, at least in part, the finding that intramammary infections by C. bovis may offer protection against intramammary infections by major pathogens.

Results

Milk samples from quarters infected with C. bovis showed a lower percentage of macrophages but an increased number of milk macrophages per mL and a higher percentage of macrophages that produced intracellular RONS and phagocytosed S. aureus. No effect of C. bovis infection on macrophage viability was found. Udder quarters infected by C. bovis showed a higher percentage of T cells and CD4+ T lymphocytes, but no effect was found on the percentage of CD8+ CD4- T, CD8- CD4- T, or B lymphocytes. Conclusions: Thus, our results corroborate, at least in part, the finding that intramammary infections by C. bovis may offer protection against intramammary infections by major pathogens.

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