Mechanistic insight into the interaction of gastrointestinal mucus with oral diblock copolymers synthesized via ATRP method
通过 ATRP 方法合成的口服嵌段共聚物与胃肠粘液相互作用的机理研究
阅读：9
作者：Jiao Liu #, Jie Cao #, Jianhua Cao, Shangcong Han, Yan Liang, Mingfeng Bai, Yong Sun
Conclusion
These results provide insights into developing optimal nanocarriers for oral administration.
Methods
We synthesized a series of diblock copolymers via the atom transfer radical polymerization method and investigated the GI mucus permeability in vitro and in vivo.
Results
Our results indicated that uncharged and hydrophobic copolymers exhibited enhanced GI absorption.
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