Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study

荷兰医护人员中四种不同 SARS-CoV-2 疫苗诱发的针对 SARS-CoV-2 变体的抗体反应：一项前瞻性队列研究

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作者：Marit J van Gils, Ayesha Lavell, Karlijn van der Straten, Brent Appelman, Ilja Bontjer, Meliawati Poniman, Judith A Burger, Melissa Oomen, Joey H Bouhuijs, Lonneke A van Vught, Marleen A Slim, Michiel Schinkel, Elke Wynberg, Hugo D G van Willigen, Marloes Grobben, Khadija Tejjani, Jacqueline van Rij

期刊：

PLoS Medicine

影响因子：

10.500

时间：

2022

起止号：

2022 May 17;19(5):e1003991.

doi：

10.1371/journal.pmed.1003991

研究方向：

免疫

疾病类型：

新冠

Background

Emerging and future SARS-CoV-2 variants may jeopardize the effectiveness of vaccination campaigns. Therefore, it is important to know how the different vaccines perform against diverse SARS-CoV-2 variants.

Conclusions

Overall, this study shows that the mRNA vaccines appear superior to adenovirus vector-based vaccines in inducing neutralizing antibodies against VOCs four weeks after initial vaccination and after booster vaccination, which implies the use of mRNA vaccines for both initial and booster vaccination.

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