CD44v6-Peptide Functionalized Nanoparticles Selectively Bind to Metastatic Cancer Cells
CD44v6-肽功能化纳米粒子选择性结合转移性癌细胞
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作者:Linxian Li, Mark Schmitt, Alexandra Matzke-Ogi, Parvesh Wadhwani, Veronique Orian-Rousseau, Pavel A Levkin
| 期刊: | Advanced Science | 影响因子: | |
| 时间: | 2016 | 起止号: | 2016 Dec 20;4(1):1600202. |
| doi: | 10.1002/advs.201600202 | 研究方向: | 免疫、细胞生物学 |
| 细胞类型: | 肿瘤细胞 | |
Abstract
CD44v6 peptide functionalized nanoparticles are fabricated in a facile and controllable way to selectively bind to CD44v6 positive tumor cells with highly efficient anticancer and antimetastatic properties. The reported modular synthesis and facile preparation makes this system highly potent for developing novel multifunctional nanocarriers for therapeutic and/or diagnostic anticancer applications.
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