Tnni3k influences cardiomyocyte S-phase activity and proliferation

Tnni3k 影响心肌细胞 S 期活性和增殖

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作者:Alexandra L Purdy, Samantha K Swift, Henry M Sucov, Michaela Patterson

Abstract

Cardiomyocyte proliferation is a difficult phenomenon to capture and prove. Here we employ a retrospective analysis of single cell ventricular suspensions to definitively identify cardiomyocytes that have completed cell division. Through this analysis we determined that the capacity of cardiomyocytes to re-enter the cell cycle and complete cell division after injury are separate and variable traits. Further, we provide evidence that Tnni3k definitively influences both early and final stages of the cell cycle.

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