First case report of a NUP98-PMX1 rearrangement in de novo acute myeloid leukemia and literature review

The nucleoporin 98 (NUP98)-paired related homeobox 1 (PMX1) fusion gene, which

This is the first report of a patient with de novo AML carrying the NUP98-PMX1 fusion gene. The reported case may contribute to a more comprehensive profile of the NUP98-PMX1 rearrangement, but mechanistic studies are warranted to fully understand the role of this fusion gene in leukemia pathogenesis.