Development and validation of a metabolite index for obstructive sleep apnea across race/ethnicities

跨种族/民族阻塞性睡眠呼吸暂停代谢物指数的开发和验证

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作者:Ying Zhang, Debby Ngo, Bing Yu, Neomi A Shah, Han Chen, Alberto R Ramos, Phyllis C Zee, Russell Tracy, Peter Durda, Robert Kaplan, Martha L Daviglus, Stephen S Rich, Jerome I Rotter, Jianwen Cai, Clary Clish, Robert Gerszten, Bruce S Kristal, Sina A Gharib, Susan Redline, Tamar Sofer0

Methods

(1) association analysis of individual metabolites, and (2) least absolute shrinkage and selection operator (LASSO) regression to identify a subset of metabolites jointly associated with OSA, which was used to develop a metabolite index for OSA.

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