Green Synthesis of Lutein-Based Carbon Dots Applied for Free-Radical Scavenging within Cells

基于叶黄素的碳点的绿色合成及其在细胞内自由基清除中的应用

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作者:Dian Yang, Li Li, Lei Cao, Zhimin Chang, Qian Mei, Ruhong Yan, Mingfeng Ge, Chenyu Jiang, Wen-Fei Dong

Abstract

Reactive oxygen species (ROS) in the body play an important role in various processes. It is well known that harmful high levels of ROS can cause many problems in living organisms in a variety of ways. One effective way to remove intracellular ROS is to use reducing materials that can enter the cell. Herein, we developed a strong reducing carbon nano-dot from a natural product, lutein, as an initial raw material. This is a hydrothermal synthesis method with the advantages of simplicity, high yield, mild reaction conditions, and environmental friendliness. The prepared carbon dots exhibit bright blue fluorescence, and have good water solubility and biocompatibility. In particular, the carbon dots can easily enter the cell and effectively remove ROS. Therefore, the carbon dots are thought to protect cells from oxidative damage by high levels of ROS.

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