Markers of T-cell dysfunction and not inflammaging predict the waning of humoral responses to SARS-CoV-2 mRNA booster vaccination in people with HIV

细胞功能障碍而非炎症的标志物可预测 HIV 感染者对 SARS-CoV-2 mRNA 加强疫苗的体液反应减弱

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作者：Matteo Augello, Valeria Bono, Roberta Rovito, Andrea Santoro, Camilla Tincati, Giulia Marchetti
期刊：AIDS影响因子：3.400
时间：2024起止号：2024 Nov 15;38(14):1987-1990.
doi：10.1097/QAD.0000000000004010研究方向： 免疫、细胞生物学
疾病类型： 新冠细胞类型： 其它细胞

Abstract

In this prospective longitudinal study, we evaluated the durability of humoral responses to SARS-CoV-2 mRNA booster vaccination in 93 people with HIV, exploring the possible role of T-cell dysfunction and inflammaging biomarkers in predicting antibody waning. We found that, despite a negligible influence of the inflammaging milieu, low CD4/CD8 ratio and CD4+CD127+ percentage as well as high CD8+CD38+CD45RO+ percentage are associated with faster antibody waning, in turn contributing to our understanding of the determinants of COVID-19 vaccine-elicited immune response in this population.

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