Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia

Siglec-15 促进 B 细胞急性淋巴细胞白血病逃避适应性免疫

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作者:Claire E Pillsbury, Jodi Dougan, Jennifer L Rabe, Jairo A Fonseca, Chengjing Zhou, Alyssa N Evans, Hasan Abukharma, Ona Ichoku, Gloria Gonzalez-Flamenco, Sunita I Park, Ahmed Aljudi, Deborah DeRyckere, Sharon M Castellino, Sarwish Rafiq, Solomon Langermann, Linda N Liu, Curtis J Henry, Christopher C

Significance

We demonstrate that Sig15 is overexpressed in hematologic malignancies driven by NFκB, is required for immune evasion in a mouse model of leukemia, and, for the first time, that it circulates at high levels in the plasma of children with leukemia.

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