Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

前列腺癌尿液外泌体:前列腺癌生物标志物的新方法

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作者:J Nilsson, J Skog, A Nordstrand, V Baranov, L Mincheva-Nilsson, X O Breakefield, A Widmark

Abstract

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.

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