Two compartment pharmacokinetic model describes the intra-articular delivery and retention of rhprg4 following ACL transection in the Yucatan mini pig
双室药代动力学模型描述了尤卡坦小型猪 ACL 横断后 rhprg4 的关节内输送和保留
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作者:Mark Hurtig, Iman Zaghoul, Heather Sheardown, Tannin A Schmidt, Lina Liu, Ling Zhang, Khaled A Elsaid, Gregory D Jay
Significance
rhPRG4 following IA delivery in a traumatized joint populates articular surfaces for a considerable period and may promote the native expression of PRG4. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:386-396, 2019.
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