The feasibility of proteomics sequencing based immune-related prognostic signature for predicting clinical outcomes of bladder cancer patients

基于蛋白质组学测序的免疫相关预后特征预测膀胱癌患者临床结果的可行性

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作者:Liren Jiang #, Siteng Chen #, Qi Pan #, Jun Zheng #, Jin He, Juanjuan Sun, Yaqin Han, Jiji Yang, Ning Zhang, Guohui Fu, Feng Gao

Background

Bladder cancer (BCa) shows its potential immunogenity in current immune-checkpoint inhibitor related immunotherapies. However, its therapeutic effects are improvable and could be affected by tumor immune microenvironment. Hence it is interesting to find some more prognostic indicators for BCa patients concerning immunotherapies.

Conclusion

The study revealed a novel BCa prognostic signature based on IRPS score, which may be useful for BCa immunotherapies.

Methods

In the present study, we retrospect 129 muscle-invasive BCa (MIBC) patients with radical cystectomy in Shanghai General Hospital during 2007 to 2018. Based on the

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