Therapeutic potential of Capparis spinosa in experimental model of acute acetic acid-induced colitis: Anti-inflammatory and antioxidant effects

山柑在急性乙酸诱发结肠炎实验模型中的治疗潜力:抗炎和抗氧化作用

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作者:Faezeh HosseiniRavesh, AmirAli Moodi Ghalibaf, Vahid Reza Askari, Farzad Fayedeh, Vafa Baradaran Rahimi, Leila Etemad, Zhila Taherzadeh

Conclusion

The study highlights caper may be useful in the treatment of acute colitis due to its ameliorative effects on inflammation, oxidative stress, and tissue repair.

Results

The results showed that administering different doses of caper led to significant decreases in TNF-α and IL-6 levels when compared to the control colitis group (p < 0.001). Caper treatment effectively lowered elevated oxidative stress factors (MDA, NO, and MPO) compared to the control colitis group (p < 0.001). Caper treatment resulted in a significant increase in antioxidant factors (CAT, SOD, and GSH) compared with the control colitis group (p < 0.001).Significant improvements in tissue repair were observed in caper-treated groups compared to positives and control colitis (p < 0.001).

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