Characterization of the C6D7-RBD Human Monoclonal Antibody Specific to the SARS-CoV-2 S Protein Receptor-Binding Domain

针对 SARS-CoV-2 S 蛋白受体结合域的 C6D7-RBD 人单克隆抗体的表征

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作者:Ya O Romanenko, M V Silkina, A S Kartseva, M A Marin, M A Shkuratova, M A Makarova, A K Ryabko, D A Konyshkova, N A Zeninskaya, A E Khlyntseva, I G Shemyakin, V V Firstova

Abstract

The new coronavirus infection COVID-19 is an acute viral disease that affects primarily the upper respiratory tract. The etiological agent of COVID-19 is the SARS-CoV-2 RNA virus (Coronaviridae family, Betacoronavirus genus, Sarbecovirus subgenus). We have developed a high-affinity human monoclonal antibody, called C6D7-RBD, which is specific to the S protein receptor-binding domain (RBD) from the SARS-CoV-2 Wuhan-Hu-1 strain and exhibits virus-neutralizing activity in a test with recombinant antigens: angiotensin-converting enzyme 2 (ACE2) and RBD.

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