Evaluation of YO-PRO-1 as an early marker of apoptosis following radiofrequency ablation of colon cancer liver metastases

YO-PRO-1作为结肠癌肝转移射频消融术后细胞凋亡早期标志物的评价

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作者:Sho Fujisawa, Yevgeniy Romin, Afsar Barlas, Lydia M Petrovic, Mesruh Turkekul, Ning Fan, Ke Xu, Alessandra R Garcia, Sebastien Monette, David S Klimstra, Joseph P Erinjeri, Stephen B Solomon, Katia Manova-Todorova, Constantinos T Sofocleous

Conclusion

This is the first time that YP1 was applied in liver parenchymal tissue (rather than cell culture). The results suggest that YP1 is a very sensitive marker of early cellular events reflecting an early and widespread plasma membrane injury that allows YP1 penetration into the cells.

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