A common variant close to the "tripwire" linker region of NLRP1 contributes to severe COVID-19

NLRP1“绊线”连接区附近的常见变体导致严重的 COVID-19

阅读：5
作者：Vinicius N C Leal, Leandro M Paulino, Raylane A G Cambui, Thiago G Zupelli, Suemy M Yamada, Leonardo A T Oliveira, Valéria de F Dutra, Carolina B Bub, Araci M Sakashita, Ana Paula H Yokoyama, José M Kutner, Camila A Vieira, Wellyngton M de S Santiago, Milena M S Andrade, Franciane M E Teixeira, Rica
期刊：Inflammation Research影响因子：4.800
时间：2023起止号：2023 Nov;72(10-11):1933-1940.
doi：10.1007/s00011-022-01670-3研究方向： 免疫
疾病类型： 新冠

Conclusion

Inflammasome genetic background contributes to individual response to SARS-CoV-2.

Methods

To address this question, we performed an association study of NLRP1, DPP9, CARD8, IL1B, and IL18 single nucleotide variants (SNVs) in a cohort of 945 COVID-19 patients.

Results

The NLRP1 p.Leu155His in the linker region, target of viral protease, was significantly associated to COVID-19 severity, which could contribute to the excessive cytokine release reported in severe cases.

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