Activation of the Mevalonate Pathway in Response to Anti-cancer Treatments Drives Glioblastoma Recurrences Through Activation of Rac-1
抗癌治疗激活甲羟戊酸通路，通过激活 Rac-1 导致胶质母细胞瘤复发
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作者：Ling He, Angeliki Ioannidis, Carter J Hoffman, Evelyn Arambula, Purva Joshi, Julian Whitelegge, Linda M Liau, Harley I Kornblum, Frank Pajonk
Significance
Combination therapies that activate the mevalonate pathway in GBM cells after sublethal treatment enhance self-renewal and migratory capacity through Rac-1 activation, which creates a metabolic vulnerability that can be further potentially exploited using statins.
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