Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis

使用集成 scRNA-seq、CyTOF 和 CITE-seq 分析全面表征多发性骨髓瘤免疫微环境

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作者:Lijun Yao, Reyka G Jayasinghe, Brian H Lee, Swati S Bhasin, William Pilcher, Deon Bryant Doxie, Edgar Gonzalez-Kozlova, Surendra Dasari, Mark A Fiala, Yered Pita-Juarez, Michael Strausbauch, Geoffrey Kelly, Beena E Thomas, Shaji K Kumar, Hearn Jay Cho, Emilie Anderson, Michael C Wendl, Travis Dawson

Significance

scRNA-seq, CyTOF, and CITE-seq are increasingly used for evaluating cellular heterogeneity. Understanding their concordances is of great interest. To date, this study is the most comprehensive examination of the measurement of the immune microenvironment in multiple myeloma using the three techniques. Moreover, we identified markers predicted to be significantly associated with multiple myeloma rapid progression.

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