Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities
表征赫尔特尔细胞癌的免疫微环境和新抗原景观以识别潜在的免疫学弱点
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作者：Ian Ganly, Fengshen Kuo, Vladimir Makarov, Yiyu Dong, Ronald Ghossein, Bin Xu, Luc G T Morris, Timothy A Chan
Significance
The immune landscape of HCC is poorly defined and response rates to immunotherapy have not been reported. The authors found the immune microenvironment in HCC to be depleted. This immunosuppression is associated with a global LOH from haploidization and uniparental disomy, resulting in whole chromosome losses across the genome.
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