Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors

小鼠急性胰腺炎中衰老和酒精相关的空间转录组特征揭示了炎症的异质性和潜在的致病因素

阅读：16

作者：Rachel R Tindall #, Yuntao Yang #, Isabella Hernandez, Amy Qin, Jiajing Li, Yinjie Zhang, Thomas H Gomez, Mamoun Younes, Qiang Shen, Jennifer M Bailey-Lundberg, Zhongming Zhao, Daniel Kraushaar, Patricia Castro, Yanna Cao, W Jim Zheng, Tien C Ko2

期刊：

Journal of Molecular Medicine-Jmm

影响因子：

时间：

2024

起止号：

2024 Aug;102(8):1051-1061.

doi：

10.1007/s00109-024-02460-6

研究方向：

免疫

信号通路：

Senescence

Key messages

Mechanisms regarding high mortality of AAP in aging remain undefined. An aging AAP mouse model was developed recapturing clinical exhibition in humans. Spatial transcriptomics identified contrasted DEGs in aging vs. young AAP mice. Top five DEGs were Mmp8, Ppbp, Serpina3m, Cxcl13, and Hamp in aging vs. young AAP mice. Our findings shed insights for identification of molecular drivers in aging AAP.

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