Conclusions
Serum MCP-1 concentration was found to be, approximately one and half folds higher in gingivitis patients (group II) and three folds higher in chronic periodontitis patients (group III) as compared to healthy subjects (group I). Further, the MCP-1 concentration increased proportionally with the severity of disease in group II and III showing positive correlation with clinical parameters. Thus, its role as an inflammatory biomarker in periodontal disease can be proposed.
Results
The mean MCP-1 concentration in serum was found to be the highest in group III i.e. 465.80 pg/ml and lowest in group I i.e. 155.20 pg/ml. For group II (251.60 pg/ml) and group IV (263.20 pg/ml) the mean MCP-1 concentrations were found to lie in between the concentrations obtained in group I and III. Conclusions: Serum MCP-1 concentration was found to be, approximately one and half folds higher in gingivitis patients (group II) and three folds higher in chronic periodontitis patients (group III) as compared to healthy subjects (group I). Further, the MCP-1 concentration increased proportionally with the severity of disease in group II and III showing positive correlation with clinical parameters. Thus, its role as an inflammatory biomarker in periodontal disease can be proposed.