Immunopharmacology of CpG oligodeoxynucleotides and ribavirin
CpG 寡脱氧核苷酸和利巴韦林的免疫药理学
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作者：Jörg Vollmer, Robert Rankin, Hanna Hartmann, Marion Jurk, Ulrike Samulowitz, Tanja Wader, Andrea Janosch, Christian Schetter, Arthur M Krieg
Abstract
To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.
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