Assessment of Antimicrobial and Cytotoxic Activities of Liposomes Loaded with Curcumin and Lippia origanoides Essential Oil

载有姜黄素和利福平精油的脂质体的抗菌和细胞毒活性评估

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作者:Juan Pablo Bedoya-Agudelo, Jhon Esteban López-Carvajal, Edwin Stiven Quiguanás-Guarín, Nestor Cardona, Leonardo Padilla-Sanabria, Jhon Carlos Castaño-Osorio

Conclusions

Encapsulation in liposomes was demonstrated to be a promising strategy for natural compounds possessing antimicrobial activity.

Methods

Liposomes were produced using the thin-layer method and physiochemical characteristics were calculated. The antimicrobial and cytotoxic activities of both encapsulated and non-encapsulated compounds were evaluated. (3)

Results

Empty and loaded nanometric-sized liposomes were obtained that are monodisperse and have a negative zeta potential. They inhibited the growth of Staphylococcus aureus and did not exhibit cytotoxic activity against mammalian cells. (4) Conclusions: Encapsulation in liposomes was demonstrated to be a promising strategy for natural compounds possessing antimicrobial activity.

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