In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model

鞣花酸在果蝇感染模型中对抗白色念珠菌的体内功效

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作者:Aline da Graça Sampaio, Aline Vidal Lacerda Gontijo, Helena Marcolla Araujo, Cristiane Yumi Koga-Ito

Abstract

The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis.

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