Prevalence of virological and serological markers of SARS-CoV-2 infection in the population of Ribeirão Preto, Southeast Brazil: an epidemiological survey

巴西东南部里贝朗普雷图人口中 SARS-CoV-2 感染病毒学和血清学标志物的流行情况:一项流行病学调查

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作者:Edson Zangiacomi Martinez, Afonso Dinis Costa Passos, Amaury Lelis Dal Fabbro, Anderson Soares da Silva, Andreia Cássia Escarso, Antônio Pazin-Filho, Benedito Antônio Lopes da Fonseca, Benedito Carlos Maciel, Daniel Cardoso de Almeida E Araújo, Diego Villa Clé, Gilberto Gambero Gaspar, Jair Lício Fe

Conclusions

The findings of this study provide in-depth knowledge of the COVID-19 pandemic in Brazil and are helpful for the preventive and decision-making policies of public managers.

Methods

The survey was conducted in two phases using a clustered sampling scheme. The first phase spanned May 1-3 and involved 709 participants. The second phase spanned June 11-14, 2020, and involved 646 participants.

Results

During the first phase, RT-PCR performed on nasopharyngeal swabs was positive at 0.14%. The serological tests were positive in 1.27% of the patients during the first phase and 2.79% during the second phase. People living in households with more than five members had a prevalence of 10.83% (95%CI: 1.58-74.27) higher than those living alone or with someone other. Considering the proportion of the positive serological test results with sex and age adjustments, approximately 2.37% (95%CI: 1.32-3.42) of the population had been cumulatively infected by mid-June 2020, which is equivalent to 16,670 people (95%CI: 9,267-24,074). Considering that 68 deaths from the disease in the residents of the city had been confirmed as at the date of the second phase of the survey, the infection fatality rate was estimated to be 0.41% (95%CI: 0.28-0.73). Our results suggest that approximately 88% of the cases of SARS-CoV-2 infection at the time of the survey were not reported to the local epidemiological surveillance service. Conclusions: The findings of this study provide in-depth knowledge of the COVID-19 pandemic in Brazil and are helpful for the preventive and decision-making policies of public managers.

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